This comparative analysis of structures and performances of the dairy supply chain in 20 south-eastern and eastern European countries shows that even after many years of structural change, the sector is still dominated by small-scale and subsistence farming, which results in weak vertical integration in all countries except the Czech Republic, Slovakia, Cyprus and Malta. Industry performances indicate positive tendencies in the Baltic States and Poland, while the sector faces serious difficulties in others. In Romania, Bulgaria and all (potential) candidate countries, the industry has immense problems complying with food quality and safety standards. Vast investments are needed in all parts of the supply chain to increase productivity and improve the quality of products. A major restructuring of the supply chain is expected in upcoming years.